Juvenile xanthogranuloma
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ReferencesJuvenile xanthogranuloma (JXG) ndi vuto komanso mtundu wa non‑Langerhans cell histiocytic disorder kwa ana. Pafupifupi 75 % ya milandu, zotupa zimawonekera mu chaka choyamba cha moyo, ndipo odwala 15‑20 % amakhala nawo kuyambira kubadwa. Ngakhale kuti ndizosowa kwa akuluakulu, JXG imapezeka nthawi zambiri mwa anthu omwe ali ndi zaka za m'ma makumi awiri mpaka makumi atatu, ndipo odwala ambiri amakhala ndi zotupa chimodzi chokha. Zachipatala, zimawoneka ngati zotupa zokha kapena zambiri, zokhala ndi chithunzi choyera‑orange‑brown, zothumba, makamaka pa maso, khosi, ndi thupi waukulu. Zilonda zapakamwa ndi zochepa ndipo nthawi zambiri zimawoneka ngati zotupa yoyera pa mbali ya mbali ya chilankhulo. Zilonda zapakamwa zingapezeka pa mazira, m'mutu wa mazira, ndi pa mpanda wamtunda wopanda mthunzi, ndipo zimatha kulowa ndi kutuluka magazi. Zilonda zapakhungu nthawi zambiri sizimayambitsa zizindikiro ndipo zimachoka zokha kwa zaka zingapo. Ngakhale kuti ndizosowa, kukhudzidwa kwa maso ndi malo omwe amakhala okhazikika kwambiri kupitirira khungu, kenako mapapu. Ocular JXG nthawi zambiri imakhudza diso limodzi lokha ndipo imapezeka pa odwala osachepera 0.5 %, ngakhale pafupifupi 40 % ya omwe ali ndi vuto la maso amakhalanso ndi zotupa zambiri pa khungu.
Juvenile xanthogranuloma (JXG) is a relatively common entity and is the most common form of non-Langerhans cell histiocytic disorder of childhood., It is estimated that in 75% of cases, lesions appear during the first year of life, with >15-20% of patients having lesions at birth. JXG is rare in adults, with a peak incidence in the late twenties to thirties. The majority of adult patients have solitary lesions. Typically, the clinical presentation consists of solitary or multiple yellow-orange-brown firm papules or nodules. The most common locations are the face, neck, and upper torso. Oral lesions are rare and often occur as a yellow nodule on the lateral aspects of the tongue. Oral lesions can also arise on the gingival, buccal mucosa, and midline hard palate and may ulcerate and bleed. Cutaneous lesions are usually asymptomatic, and most lesions spontaneously involute over the course of several years. Although occurring rarely, ocular involvement is the most common extracutaneous site involved, followed by the lungs. Ocular JXG is nearly always unilateral and develops in less than 0.5% of patients. Approximately 40% of patients with ocular JXG, however, have multiple cutaneous lesions at the time of diagnosis.
Juvenile xanthogranuloma (JXG) is a relatively common entity and is the most common form of non-Langerhans cell histiocytic disorder of childhood., It is estimated that in 75% of cases, lesions appear during the first year of life, with >15-20% of patients having lesions at birth. JXG is rare in adults, with a peak incidence in the late twenties to thirties. The majority of adult patients have solitary lesions. Typically, the clinical presentation consists of solitary or multiple yellow-orange-brown firm papules or nodules. The most common locations are the face, neck, and upper torso. Oral lesions are rare and often occur as a yellow nodule on the lateral aspects of the tongue. Oral lesions can also arise on the gingival, buccal mucosa, and midline hard palate and may ulcerate and bleed. Cutaneous lesions are usually asymptomatic, and most lesions spontaneously involute over the course of several years. Although occurring rarely, ocular involvement is the most common extracutaneous site involved, followed by the lungs. Ocular JXG is nearly always unilateral and develops in less than 0.5% of patients. Approximately 40% of patients with ocular JXG, however, have multiple cutaneous lesions at the time of diagnosis.
Juvenile xanthogranulomas (JXGs) ndi matenda opanda chiwawa omwe ali mgulu lalikulu la non-Langerhans cell histiocytoses. Amawoneka ngati zotupa zofiira kapena zachikasu, zomwe nthawi zambiri zimapezeka pamutu kapena pakhosi. Ma JXG ambiri amakula pobadwa kapena m'chaka choyamba cha moyo. Ngakhale ndi matenda opanda chiwawa, nthawi zina zimatha kukhudza madera omwe ali kunja kwa khungu, ndi kuwonongeka kwa maso kukhala chinthu choyenera kuyang'ana malinga ndi mabuku omwe alipo. Nthawi zambiri, ma JXG pakhungu amapita okha ndipo safuna chithandizo.
Juvenile xanthogranulomas (JXGs) are uncommon, benign diseases that are part of a larger category of non-Langerhans cell histiocytoses. They typically show up as one or more red or yellowish lumps, often found on the head or neck. Most JXGs develop either at birth or within the first year of life. While it's unusual, sometimes they can affect areas beyond the skin, with eye involvement being something to watch for according to existing literature. Generally, JXGs on the skin go away on their own and typically don't need treatment.
Juvenile xanthogranulomas (JXGs) are uncommon, benign diseases that are part of a larger category of non-Langerhans cell histiocytoses. They typically show up as one or more red or yellowish lumps, often found on the head or neck. Most JXGs develop either at birth or within the first year of life. While it's unusual, sometimes they can affect areas beyond the skin, with eye involvement being something to watch for according to existing literature. Generally, JXGs on the skin go away on their own and typically don't need treatment.
Zilonda zam’maso zimawonekera mpaka 10 % mwa anthu omwe ali ndi JXG ndipo zingakhudze masomphenya awo. Ngakhale kuti zotupa za pakhungu nthawi zambiri zimazimiririka zokha, zotupa m'maso sizingochitika zokha ndipo zimafunikira chithandizo.